thromboxane a2 การใช้

• Thromboxane A2 ( TX2 ) has a positive feedback in platelet activation.
• It is associated with a deficiency of Thromboxane-A synthase, which produces Thromboxane A2.
• In this case, the greater aggregation of platelets produce ADP, serotonin, and thromboxane A2.
• Receptors that mediate TXA2 actions are thromboxane A2 receptors.
• Thromboxane A2 is also a known vasoconstrictor and is especially important during tissue injury and inflammation.
• "' Ozagrel "'( INN ) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.
• This product is further metabolized by Thromboxane synthase to "'Thromboxane A2 "', "'12-Hydroxyheptadecatrienoic acid "', and malonyldialdehyde.
• It is produced by the oxygenation of arachidonic acid by two enzymes : cycloxygenase and thromboxane A2 synthase.
• These " Sticky platelets " secrete several chemicals, including thromboxane A2 that stimulate vasoconstriction, reducing blood flow at the site.
• It itself is not involved in platelet activation and aggregation in case of a wound, but its precursor, thromboxane A2, is.
• Aspirin works by blocking the formation of thromboxane A2, a chemical in the body that makes platelets sticky and promotes blood clotting.
• However the serotonin and the thromboxane A2 cause more contraction of the smooth muscle cells and as a result contractions outweigh the relaxations.
• Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme ( the source of thromboxane A2 in platelets ).
• Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme ( the source of thromboxane A2 in platelets ).
• It is a prominent product in Thromboxane A2 synthesis wherein cyclooxygenase 1 or cycloxygenase 2 metabolizes arachidonic acid to prostaglandin H2 by platelets and a wide array of other cell types and tissues.
• 25I-NBOMe presumably exhibits functional selectivity at the 5HT 2A receptor similar to other phenethylamine hallucinogens, activating the Phospholipase A2 signal cascade, which is responsible for the release of Thromboxane A2, triggering blood platelet aggregation.
• Its derived PGS have lost this oxygen bridge and contain a single, unsaturated 5-carbon ring with the exception of thromboxane A2 which possesses a 6-member ring consisting of one oxygen and 5 carbon atoms.
• 12 ( " S " )-HETE and 12 ( " R " )-HETE bind to and act as Competitive antagonists of the Thromboxane receptor which mediates the actions of Thromboxane A2 and Prostaglandin H2.
• "' Thromboxane A2 "'( TXA2 ) is a type of thromboxane that is produced by activated platelets and has prothrombotic properties : it stimulates activation of new platelets as well as increases platelet aggregation.
• This antagonistic activity was responsible for the ability of 12 ( " S " )-HETE and 12 ( " R " )-HETE to relax mouse mesenteric arteries pre-constricted with a thromboxane A2 mimetic, U46619.